Preferred Label : Anti-FRa Antibody-drug Conjugate AZD5335;
NCIt synonyms : Anti-folate Receptor Alpha Antibody-drug Conjugate AZD5335; Anti-FRa ADC AZD5335;
NCIt definition : An antibody-drug conjugate (ADC) composed of a human monoclonal antibody targeting
folate receptor alpha (FRa; FolRa; FOLR1) conjugated to a camptothecin-based topoisomerase
1 inhibitor AZ14170132, with potential antineoplastic activity. Upon administration
of anti-FRa ADC AZD5335, the antibody moiety targets and binds to FRa expressed on
tumor cells. Upon binding, cellular uptake and linker cleavage, AZ14170132 is released.
AZ14170132 inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication
and generating DNA single- and double-strand breaks, and leading to cell cycle arrest
and tumor cell apoptosis. This inhibits the proliferation of FRa-expressing tumor
cells. FRa is a glycosylphosphatidylinositol linked cell-surface glycoprotein that
is widely expressed in certain cancers while its expression is limited in normal tissues.;
Molecule name : AZD-5335; AZD 5335;
NCI Metathesaurus CUI : CL1907332;
Origin ID : C200057;
UMLS CUI : C5854465;
Semantic type(s)
- concept_is_in_subset
- has_target
