Preferred Label : Torvutatug Samrotecan;
NCIt synonyms : Anti-folate Receptor Alpha Antibody-drug Conjugate AZD5335; Anti-FRa ADC AZD5335; Anti-FRa Antibody-drug Conjugate AZD5335;
NCIt definition : An antibody-drug conjugate (ADC) composed of torvutatug, a human monoclonal antibody
targeting folate receptor alpha (FRa; FolRa; FOLR1) conjugated to samrotecan, a linker
conjugated to exatecan, with potential antineoplastic activity. Upon administration
of torvutatug samrotecan, the antibody moiety targets and binds to FRa expressed on
tumor cells. Upon binding, cellular uptake and linker cleavage, exatecan is released
and inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and
generating DNA single- and double-strand breaks, and leading to cell cycle arrest
and tumor cell apoptosis. This inhibits the proliferation of FRa-expressing tumor
cells. FRa is a glycosylphosphatidylinositol linked cell-surface glycoprotein that
is widely expressed in certain cancers while its expression is limited in normal tissues.;
UNII : E5QZ8ZF3HE;
CAS number : 2975630-26-1;
Molecule name : AZD-5335; AZD 5335;
NCI Metathesaurus CUI : CL1907332;
Origin ID : C200057;
UMLS CUI : C5854465;
Semantic type(s)
- concept_is_in_subset
- has_target
