Preferred Label : Multi-epitope Folate Receptor Alpha-loaded Dendritic Cell Vaccine;
NCIt synonyms : FRalphaDC Vaccine; FRaDC Vaccine;
NCIt definition : A cell-based vaccine composed of autologous-monocyte-derived dendritic cells (DCs)
loaded with five immunogenic peptide epitopes, derived from the tumor-associated antigen
human folate receptor alpha (FR alpha or FOLR1), including FR30, FR56, FR76, FR113,
and FR238, with potential immunomodulatory and antineoplastic activity. Ex vivo treatment
of the DCs with a p38 inhibitor decreases p38-mediated signaling and enhances ERK
activation. This may allow, upon intradermal administration of the multi-epitope FR
alpha-loaded DC vaccine into the patient, for decreased activation and expansion of
CD4 regulatory T-cells (Tregs), increased differentiation and expansion of interleukin-17
secreting T helper cells (Th17) and activation of CD8 CTLs, which induces a strong
anti-tumor T-cell immune response against FR alpha-overexpressing tumor cells. FR
alpha is a high-affinity folate-binding protein and a member of the folate receptor
family; this receptor is overexpressed in the majority of ovarian cancers and in about
approximately 50% of breast cancers.;
Origin ID : C114990;
UMLS CUI : C3896672;
Semantic type(s)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
