Preferred Label : Luveltamab Tazevibulin;
NCIt synonyms : Anti-FolRa ADC STRO-002; Anti-FolRalpha ADC STRO-002; Anti-Folate Receptor-alpha Antibody Drug Conjugate STRO-002;
NCIt definition : An antibody drug conjugate (ADC) composed of SP8166 (H01), an anti-folate receptor
alpha (FolRa; FOLR1) human immunoglobulin G1 (IgG1) antibody, conjugated to a proprietary
cleavable drug linker, SC239, containing a tubulin-targeting 3-aminophenyl hemiasterlin
warhead, SC209, with potential antineoplastic activity. Upon intravenous administration,
the SP8166 antibody moiety targets and binds to FolRa expressed on certain tumor cells.
Upon binding, internalization, and enzymatic cleavage, the cytotoxic SC209 moiety
induces tumor cell death in FolRa-expressing cells. FolRa is a glycosylphosphatidylinositol
linked cell-surface glycoprotein that is widely expressed in certain cancers including
serous and epithelial ovarian cancer, endometrial adenocarcinoma, non-small cell lung
cancer and triple negative breast cancer. In contrast, FolRa expression is limited
in normal tissues.;
UNII : XDE2GOF1JT;
CAS number : 2493327-62-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2493327-62-9
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : STRO-002; STRO 002;
NCI Metathesaurus CUI : CL937710;
Origin ID : C158067;
UMLS CUI : C5708880;
Semantic type(s)
- concept_is_in_subset
- has_target
