Preferred Label : Lutetium Lu 177-EVS459;
NCIt synonyms : Lutetium Lu 177-EVS-459; [177Lu]Lu-EVS459; Lutetium Lu 177 EVS459; [177Lu]-EVS459; 177Lu-EVS459;
NCIt definition : A radioconjugate composed of EVS459, a folate receptor alpha (FRa; FolRa; FOLR1)-targeting
moiety, radiolabeled with the beta-emitting radioisotope lutetium Lu 177 (177Lu),
with potential antineoplastic activity. Upon administration of lutetium Lu 177-EVS459,
the FOLR1-targeting moiety targets and binds to FOLR1 expressed on tumor cells. Upon
binding, FOLR1-expressing tumor cells are destroyed by 177Lu through the specific
delivery of beta particle radiation. FOLR1 is a glycosylphosphatidylinositol linked
cell-surface glycoprotein that is widely expressed in certain cancers while its expression
is limited in normal tissues.;
Origin ID : C211691;
concept_is_in_subset
- has_target
