Preferred Label : Anti-FOLR1 CAR T-cells;
NCIt synonyms : FH-FOLR1 CAR T Cells; Anti-FOLR1 CAR-T Cells;
NCIt definition : A preparation of T-lymphocytes that have been engineered to express a chimeric antigen
receptor (CAR) specific for folate receptor alpha (FolRa; FOLR1), with potential immunostimulating
and antineoplastic activities. Upon administration, anti-FOLR1 CAR T-cells specifically
recognize and bind to FOLR1-expressing tumor cells, resulting in specific T-cell-mediated
tumor cell lysis. FOLR1 is a glycosylphosphatidylinositol linked cell surface glycoprotein
that is widely expressed in certain cancers while its expression is limited in normal
tissues.;
Origin ID : C209362;
concept_is_in_subset
- has_target
