Preferred Label : Anti-FRalpha Antibody-drug Conjugate ZW191;
NCIt synonyms : Anti-FRalpha ADC ZW191; Anti-FRa/ZD06519 ADC ZW191; Anti-FRa ADC ZW191;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
monoclonal antibody targeting folate receptor alpha (FRa; FolRa; FOLR1) conjugated,
via a maleimidocaproyl (MC) anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl
(AM) protease-cleavable linker, to the camptothecin-based topoisomerase 1 inhibitor
ZD06519, with potential antineoplastic activity. Upon administration of anti-FRalpha
ADC ZW191, the antibody moiety targets and binds to FRa expressed on tumor cells.
Upon binding, cellular uptake and linker cleavage, ZD06519 is released. ZD06519 inhibits
DNA topoisomerase I activity, thereby inhibiting DNA replication and generating DNA
single- and double-strand breaks. This leads to cell cycle arrest and tumor cell apoptosis.
In addition, ZD06519 is able to induce a bystander effect on neighboring cells in
the tumor environment. This inhibits the proliferation of tumor cells. FRa is a glycosylphosphatidylinositol
linked cell-surface glycoprotein that is widely expressed in certain cancers while
its expression is limited in normal tissues.;
Molecule name : ZW 191; ZW-191;
Origin ID : C215047;
concept_is_in_subset
- has_target
