" /> Mirvetuximab Soravtansine - CISMeF





Preferred Label : Mirvetuximab Soravtansine;

NCIt synonyms : M9346A-sulfo-SPDB-DM4; Mirvetuximab Soravtansine-gynx;

NCIt definition : An immunoconjugate consisting of the humanized monoclonal antibody M9346A against folate receptor 1 (FOLR1) conjugated, via the disulfide-containing cleavable linker sulfo-SPDB, to the cytotoxic maytansinoid DM4, with potential antineoplastic activity. The anti-FOLR1 monoclonal antibody moiety of mirvetuximab soravtansine targets and binds to the cell surface antigen FOLR1. After antibody-antigen interaction and internalization, the immunoconjugate releases DM4, which binds to tubulin and disrupts microtubule assembly/disassembly dynamics, thereby inhibiting cell division and cell growth of FOLR1-expressing tumor cells. FOLR1, a member of the folate receptor family is overexpressed on a variety of epithelial-derived cancer cells. The sulfo-SPDB linker prevents cleavage in the bloodstream and may improve this agent's efficacy in multidrug resistant tumor cells.;

UNII : 98DE7VN88D;

CAS number : 1453084-37-1;

Drug name : Elahere;

Molecule name : IMGN-853; IMGN 853;

Codes from synonyms : 109643;

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07/05/2025


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