Mirvetuximab Soravtansine

Preferred Label : Mirvetuximab Soravtansine;

NCIt synonyms : M9346A-sulfo-SPDB-DM4; Mirvetuximab Soravtansine-gynx;

NCIt definition : An immunoconjugate consisting of the humanized monoclonal antibody M9346A against folate receptor 1 (FOLR1) conjugated, via the disulfide-containing cleavable linker sulfo-SPDB, to the cytotoxic maytansinoid DM4, with potential antineoplastic activity. The anti-FOLR1 monoclonal antibody moiety of mirvetuximab soravtansine targets and binds to the cell surface antigen FOLR1. After antibody-antigen interaction and internalization, the immunoconjugate releases DM4, which binds to tubulin and disrupts microtubule assembly/disassembly dynamics, thereby inhibiting cell division and cell growth of FOLR1-expressing tumor cells. FOLR1, a member of the folate receptor family is overexpressed on a variety of epithelial-derived cancer cells. The sulfo-SPDB linker prevents cleavage in the bloodstream and may improve this agent's efficacy in multidrug resistant tumor cells.;

UNII : 98DE7VN88D;

CAS number : 1453084-37-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1453084-37-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Elahere;

Molecule name : IMGN853;

Codes from synonyms : 109643;

Details

Origin ID

C102566;

UMLS CUI

C4288736;

Currated CISMeF NLP mapping
- mirvetuximab soravtansine [MeSH Supplementary Concept]
- mirvetuximab soravtansine [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- mirvetuximab soravtansine [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Folate Receptor Alpha [NCIt concept]
is_component_of_chemotherapy_regimen
- Bevacizumab/Mirvetuximab Soravtansine Regimen [NCIt concept]
- Mirvetuximab Soravtansine Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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