Preferred Label : Opugotamig Olatansine;
NCIt synonyms : Anti-FRa ADC IMGN151; Anti-Folate Receptor Alpha ADC IMGN151; Antibody-drug Conjugate IMGN151; Anti-FRa/DM21 ADC IMGN151;
NCIt definition : An antibody-drug conjugate (ADC) composed of opugotamig, an asymmetric, bivalent,
biparatopic antibody targeting two independent epitopes of folate receptor alpha (FRa;
FolRa; FOLR1) that is conjugated, via a cleavable peptide linker, to the cytotoxic
maytansinoid derivative DM21, with potential antineoplastic activity. Upon administration
of opugotamig olatansine, the antibody moiety targets and binds to FRa expressed on
tumor cells. Upon cellular uptake and internalization, DM21 is released, binds to
tubulin and disrupts microtubule assembly/disassembly dynamics, which results in the
inhibition of both cell division and cell growth of tumor cells. FRa is a glycosylphosphatidylinositol-linked
cell surface glycoprotein, that is widely expressed in certain cancers while its expression
is limited in normal tissues.;
UNII : 8R9DRT37YD;
CAS number : 2779564-40-6;
Molecule name : IMGN-151; IMGN 151;
NCI Metathesaurus CUI : CL1905146;
Origin ID : C191851;
UMLS CUI : C5784742;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
- has_target
