Preferred Label : MOv19 CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocytes;
NCIt synonyms : MOv19-CAR-CD3zeta-4-1BB-expressing Allogeneic T-cells; Allogeneic MOv19 CAR-CD3zeta-4-1BB-expressing T-lymphocytes; Anti-Folate Receptor Alpha-CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocytes;
NCIt definition : A preparation of allogeneic CD4-positive and CD8-positive T-lymphocytes that have
been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR)
comprised of an anti-folate receptor alpha (FR-alpha; ovarian tumor-associated antigen
MOv18) single chain variable fragment (scFv) (MOv19) and the zeta chain of the T-cell
receptor (TCR)/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137),
with potential immunomodulating and antineoplastic activities. Upon administration,
MOv19-CAR-CD3zeta-4-1BB-expressing allogeneic T-lymphocytes target, bind to and induce
selective toxicity in folate receptor alpha-expressing tumor cells. The costimulatory
signaling domain enhances both proliferation of T-cells and antitumor activity. Folate
receptor alpha is a glycosylphosphatidylinositol-linked cell-surface glycoprotein
that is widely expressed in certain cancers including serous and epithelial ovarian
cancer, endometrial adenocarcinoma, non-small cell lung cancer and triple negative
breast cancer. In contrast, folate receptor alpha expression is limited in normal
tissues.;
NCI Metathesaurus CUI : CL970759;
Origin ID : C162166;
UMLS CUI : C5206385;
Semantic type(s)
- concept_is_in_subset
- has_target
