NCIt definition : An injectable targeted small molecule drug conjugate (SMDC) consisting of folate (vitamin
B9) covalently linked to the potent mitotic poison and cytotoxic agent, tubulysin
B hydrazide (Tub-B-H) with potential antineoplastic activity. Upon administration,
the folate moiety of folate receptor-targeted tubulysin conjugate EC1456 preferentially
binds to tumor cells expressing folate receptors (FR). After binding to FR, the agent
is internalized by tumor cells and the Tub-B-H moiety inhibits the polymerization
of tubulin into microtubules. This may lead to both cell cycle arrest and tumor cell
apoptosis. FR, the membrane-bound, high-affinity receptor for folate, is overexpressed
on a wide range of primary and metastatic human cancers.;
Semantic type(s)