Vintafolide - CISMeF

Preferred Label : Vintafolide;

NCIt synonyms : Folate-Vinca Alkaloid Conjugate EC145;

NCIt definition : A water-soluble, folate-receptor-targeted conjugate of folate and the vinca alkaloid desacetylvinblastine monohydrazide (DAVLBH) with potential antineoplastic activity. The folate moiety of vintafolide binds to folic acid receptors on the tumor cell surface and the agent is internalized via folate receptor-mediated endocytosis, delivering the tubulin-binding DAVLBH moiety directly into the tumor cell; DAVLBH binding to tubulin results in the disruption of microtubule assembly-disassembly dynamics, cell cycle arrest, and tumor cell apoptosis. Folic acid receptors are frequently upregulated on the surfaces of many tumor cell types. DAVLBH is a derivative of the natural product vinblastine.;

UNII : 36O410ZD4I;

InChIKey : KUZYSQSABONDME-QRLOMCMNSA-N;

CAS number : 742092-03-1;

Molecule name : EC145;

Chemical formula : C86H109N21O26S2;

Details

Origin ID

C62525;

UMLS CUI

C3530172;

Automatic exact mappings (from CISMeF team)
- EC145 [MeSH Supplementary Concept]
- Vintafolide [ICD-11 Extension code]
Currated CISMeF NLP mapping
- vintafolide [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- vintafolide [MeSH concept]
- vintafolide [ATC Code]
Validated automatic mappings to BTNT
- vintafolide [ATC Code]
chemical_or_drug_affects_gene_product
- Tubulin [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Cell Cycle [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Folate Receptor Alpha [NCIt concept]
- Tubulin [NCIt concept]

Keyword's position in hierarchy(ies) :

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