Anti-folate Receptor Alpha Antibody-drug Conjugate AMT-151

Preferred Label : Anti-folate Receptor Alpha Antibody-drug Conjugate AMT-151;

NCIt synonyms : Anti-FolRa ADC AMT-151; Anti-FRa ADC AMT-151; Anti-FOLR1 ADC AMT-151; Anti-folate Receptor Alpha ADC AMT-151;

NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting folate receptor alpha (FRa; FolRa; FOLR1) conjugated to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-FRa ADC AMT-151, the antibody moiety targets and binds to FRa expressed on tumor cells. Upon cellular uptake and internalization, the cytotoxic agent inhibits tumor cell proliferation through an as of yet undisclosed mechanism of action (MoA). FRa is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues.;

Molecule name : AMT-151; AMT 151;

NCI Metathesaurus CUI : CL1799101;

Details

Origin ID

C190686;

UMLS CUI

C5783856;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Folate Receptor Alpha [NCIt concept]

Keyword's position in hierarchy(ies) :

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