" /> Neurogenic Locus Notch Homolog Protein 4 - CISMeF





Preferred Label : Neurogenic Locus Notch Homolog Protein 4;

NCIt synonyms : Human Homolog 4 of Drosophila Notch4 Protein; Notch4 / Int3 Gene Product; NOTCH4; hNotch4; Notch4 Protein; Neurogenic Locus Notch Homolog Protein 4 Notch Homolog 4; Notch 4;

NCIt definition : Neurogenic locus notch homolog protein 4 (2003 aa, 210 kDa) is encoded by the human NOTCH4 gene. This protein plays a role in both cell-fate determination and cell-cell signaling.;

NCIt note : Neurogenic locus notch homolog protein 4 has 29 extracellular EGF-like repeats, three Notch/lin-12 repeats, a transmembrane region, six intracellular cdc10/ankyrin repeats, a polyglutamine domain, and a C-terminal PEST region. A component of an evolutionarily conserved intercellular signaling mechanism, NOTCH4 is expressed in a variety of tissues and appears to regulate cell fate decisions during embryonic vascular morphogenesis and remodeling. NOTCH4 and NOTCH1 appear to have partially overlapping roles during embryogenesis in mice. MMTV INT3 interruption of NOTCH4 produces a gain-of-function truncated product, containing only the transmembrane and intracellular domains, that has profound consequences for mammary gland development and tumorigenesis. (OMIM);

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
10/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.