Apoptosis-Stimulating of p53 Protein 2

Preferred Label : Apoptosis-Stimulating of p53 Protein 2;

NCIt synonyms : p53-Binding Protein 2; p53BP2; Tumor Protein p53 Binding Protein 2; Renal Carcinoma Antigen NY-REN-51; 53BP2; Bbp; TP53BP2; BCL-2 Binding Protein; Tumor Protein p53-Binding Protein-2;

NCIt definition : Apoptosis-stimulating of p53 protein 2 (1128 aa, 126 kDa) is encoded by the human TP53BP2 gene. This protein plays a role in cell cycle arrest and the regulation of cellular tumor antigen p53-dependent apoptosis.;

NCIt note : Apoptosis-stimulating of p53 protein 2 impedes cell cycle progression beyond G2/M. It enhances p53 trans-activation function and induces p21 (CDKN1A) expression. This protein contains ankyrin repeats and an SH3 domain, which are required for interaction with p53 and BCL2; TP53BP2 cannot bind both proteins simultaneously. (OMIM);

Details

Origin ID

C17912;

UMLS CUI

C0290923;

OMIM relation
- Tumor protein p53-binding protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TP53BP2 protein, human [MeSH concept]
- TP53BP2 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- TP53BP2 Gene [NCIt concept]
gene_product_has_biochemical_function
- Ligand Binding Protein [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ankyrin Repeat [NCIt concept]
- SH3 Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Negative Regulation of G2 to M Transition [NCIt concept]
- Regulation of Cell Death Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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