" /> Apoptosis-Stimulating of p53 Protein 2 - CISMeF





Preferred Label : Apoptosis-Stimulating of p53 Protein 2;

NCIt synonyms : p53-Binding Protein 2; p53BP2; Tumor Protein p53 Binding Protein 2; Renal Carcinoma Antigen NY-REN-51; 53BP2; Bbp; TP53BP2; BCL-2 Binding Protein; Tumor Protein p53-Binding Protein-2;

NCIt definition : Apoptosis-stimulating of p53 protein 2 (1128 aa, 126 kDa) is encoded by the human TP53BP2 gene. This protein plays a role in cell cycle arrest and the regulation of cellular tumor antigen p53-dependent apoptosis.;

NCIt note : Apoptosis-stimulating of p53 protein 2 impedes cell cycle progression beyond G2/M. It enhances p53 trans-activation function and induces p21 (CDKN1A) expression. This protein contains ankyrin repeats and an SH3 domain, which are required for interaction with p53 and BCL2; TP53BP2 cannot bind both proteins simultaneously. (OMIM);

Détails


Vous pouvez consulter :


Nous contacter.
31/07/2025


[Accueil] [Haut de page]

© CHU de Rouen. Toute utilisation partielle ou totale de ce document doit mentionner la source.