Preferred Label : A-Kinase Anchor Protein 13;
NCIt synonyms : HT31; A-Kinase (PRKA) Anchor Protein 13; P47; LBC; AKAP13; BRX; LBC Oncogene; PRKA13; Breast Cancer Nuclear Receptor-Binding Auxiliary Protein; Guanine Nucleotide Exchange Factor Lbc; Human Thyroid-Anchoring Protein 31; A Kinase Anchor Protein-13; Non-Oncogenic Rho GTPase-Specific GTP Exchange Factor; AKAP-13; Breast Cancer cDNA-Encoded Nuclear Receptor-Binding Auxillary Protein 1; Lymphoid Blast Crisis Oncogene; A Kinase Anchor Protein 13; Protein Kinase A-Anchoring Protein 13;
NCIt definition : A-kinase anchor protein 13 (2813 aa, 308 kDa) is encoded by the human AKAP13 gene.
This protein is involved in adrenergic receptor signaling, EGFR-mediated signal transduction
and guanine nucleotide exchange factor activity for transforming protein RhoA.;
NCIt note : A-kinase anchor protein 13 stimulates the activity of RHO/RAC, but not CDC42 or RAS.
In ovary, placenta, breast, and testis, an N-terminally truncated isoform called BRX
is expressed; this isoform contains a LBC region preceded by 3 novel regions and binds
to ESR1, RXR, PPAR, and THR. (OMIM);
Origin ID : C21329;
UMLS CUI : C1318045;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
