calpain - CISMeF

Preferred Label : calpain;

MeSH definition : Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.;

MeSH synonym : calcium activated neutral protease; calcium-dependent neutral protease; protease, calcium-activated neutral; neutral proteinase, calcium-dependent; proteinase, calcium-dependent neutral; neutral proteinase, calcium-activated; calcium dependent neutral proteinase; calcium-activated neutral protease; calcium activated neutral proteinase; calcium activated protease; proteinase, calcium-activated neutral; protease, calcium-dependent neutral; desminase; neutral protease, calcium-dependent; calcium-activated neutral proteinase; calcium-dependent neutral proteinase; calcium-activated protease; protease, ca2 -activated; protease, calcium-activated; calcium dependent neutral protease; ca2 -activated protease; ca2 activated protease; neutral protease, calcium-activated;

CISMeF synonym : EC 3.4.22.-; I, calpain; II, calpain;

MeSH hyponym : calpain II; calpain I;

MeSH Related Number : calpain II; calpain I; EC 3.4.22.52; EC 3.4.22.53;

Registry Number MeSH : EC 3.4.22.-;

Related CAS MeSH : EC 3.4.22.53 (Calpain II); EC 3.4.22.52 (Calpain I);

MeSH annotation : /biosyn /physiol permitted;

Is substance : O;

Details

Origin ID

D002154;

UMLS CUI

C0006784;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Caspase-2 [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-5 [NCIt concept]
- Caspase-6 [NCIt concept]
- Caspase-7 [NCIt concept]
- Caspase-9 [NCIt concept]
- Cathepsin Z [NCIt concept]
- Cysteine Proteinase [NCIt concept]
Currated CISMeF NLP mapping
- Calpain [NCIt concept]
- Calpain (substance) [SNOMED CT concept]
- calpain [SNOMED Notion]
Indexing information
- 1-(2-benzothienylcarbonyl)piperidin-4-ylcarbonyl-phenylalaninamide [MeSH Supplementary Concept]
- 1-(2-naphthylcarbonyl)piperidin-4-ylcarbonyl-phenylalaninamide [MeSH Supplementary Concept]
- 3,6-bis(4-hydroxyphenylmethyl)-1,4-dimethyl-2,5-diketopiperazine [MeSH Supplementary Concept]
- 3-(benzyloxycarbonylleucylamino)-N-(3-(4-methylpiperazin-1-yl)propyl)-2-oxopentanamide [MeSH Supplementary Concept]
- 3-(benzyloxycarbonylleucylamino)-N-(3-(6-amino-9H-purin-9-yl)propyl)-2-oxopentanamide [MeSH Supplementary Concept]
- 5-formyl-pyrrole-2-carboxylic acid (1-(1-formyl-3-methyl-butylcarbamoyl)-2-methyl-propyl)amide [MeSH Supplementary Concept]
- A 705239 [MeSH Supplementary Concept]
- A-705253 [MeSH Supplementary Concept]
- AK 275 [MeSH Supplementary Concept]
- AK 295 [MeSH Supplementary Concept]
- CEP-3453 [MeSH Supplementary Concept]
- MDL 104903 [MeSH Supplementary Concept]
- N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal [MeSH Supplementary Concept]
- N-1-(hydroxy(3-oxo-2-phenyl-1-cyclopropen-1-yl)methyl)-2-methylpropyl-2-benzenesulfonylamino-4-methylpentanamide [MeSH Supplementary Concept]
- N-methyltyrosyl-N-methyltyrosyl-leucyl-alanine [MeSH Supplementary Concept]
- PD 151746 [MeSH Supplementary Concept]
- PDCD6 protein, human [MeSH Supplementary Concept]
- Pdcd6 protein, mouse [MeSH Supplementary Concept]
- SNJ 1715 [MeSH Supplementary Concept]
- TRA-3 protein, C elegans [MeSH Supplementary Concept]
- acetyl-leucyl-leucyl-normethional [MeSH Supplementary Concept]
- acetylleucyl-leucyl-norleucinal [MeSH Supplementary Concept]
- benzyloxycarbonyl-leucyl-glucyl-tyrosine fluoromethyl ketone [MeSH Supplementary Concept]
- benzyloxycarbonyl-leucyl-leucyl-tyrosinal [MeSH Supplementary Concept]
- benzyloxycarbonyl-leucyl-methionine-H [MeSH Supplementary Concept]
- calpain inhibitor 2 [MeSH Supplementary Concept]
- calpain inhibitor III [MeSH Supplementary Concept]
- calpain inhibitors [MeSH Supplementary Concept]
- calpastat [MeSH Supplementary Concept]
- calpastatin [MeSH Supplementary Concept]
- calpeptin [MeSH Supplementary Concept]
- epicatechin 5-gallate [MeSH Supplementary Concept]
- phevalin [MeSH Supplementary Concept]
Record concept(s)
- calpain [MeSH concept]
- calpain I [MeSH concept]
- calpain II [MeSH concept]
Related MeSH Supplementary Concept(s)
- B27-HYD peptide [MeSH Supplementary Concept]
- CALPx11 protein, trypanosoma cruzi [MeSH Supplementary Concept]
- CAP5.5 protein, trypanosoma brucei [MeSH Supplementary Concept]
- CAPN1 protein, bos taurus [MeSH Supplementary Concept]
- CAPN1 protein, human [MeSH Supplementary Concept]
- CAPN11 protein, human [MeSH Supplementary Concept]
- CAPN12 protein, human [MeSH Supplementary Concept]
- CAPN14 protein, human [MeSH Supplementary Concept]
- CAPN15 protein, human [MeSH Supplementary Concept]
- CAPN2 protein, human [MeSH Supplementary Concept]
- CAPN3 protein, human [MeSH Supplementary Concept]
- CAPN6 protein, human [MeSH Supplementary Concept]
- CAPN8 protein, Xenopus [MeSH Supplementary Concept]
- CAPN8 protein, human [MeSH Supplementary Concept]
- CAPN9 protein, human [MeSH Supplementary Concept]
- CAPN9 protein, rat [MeSH Supplementary Concept]
- CAPNS1 protein, human [MeSH Supplementary Concept]
- Calm4 protein, mouse [MeSH Supplementary Concept]
- CalpB protein, drosophila [MeSH Supplementary Concept]
- Capn1 protein, mouse [MeSH Supplementary Concept]
- Capn1 protein, rat [MeSH Supplementary Concept]
- Capn11 protein, mouse [MeSH Supplementary Concept]
- Capn12 protein, mouse [MeSH Supplementary Concept]
- Capn2 protein, mouse [MeSH Supplementary Concept]
- Capn2 protein, rat [MeSH Supplementary Concept]
- Capn3 protein, mouse [MeSH Supplementary Concept]
- Capn3 protein, rat [MeSH Supplementary Concept]
- Capn5 protein, human [MeSH Supplementary Concept]
- Capn5 protein, mouse [MeSH Supplementary Concept]
- Capn6 protein, mouse [MeSH Supplementary Concept]
- Capn7 protein, human [MeSH Supplementary Concept]
- Capn7 protein, mouse [MeSH Supplementary Concept]
- Capn8 protein, mouse [MeSH Supplementary Concept]
- Capn9 protein, mouse [MeSH Supplementary Concept]
- Capns1 protein, mouse [MeSH Supplementary Concept]
- Capns1 protein, rat [MeSH Supplementary Concept]
- DEK1 protein, arabidopsis [MeSH Supplementary Concept]
- TRA-3 protein, C elegans [MeSH Supplementary Concept]
- XCL-2 calpain [MeSH Supplementary Concept]
- calpain 10 [MeSH Supplementary Concept]
- calpain 5, rat [MeSH Supplementary Concept]
- calpain A, drosophila [MeSH Supplementary Concept]
- calpain C, drosophila [MeSH Supplementary Concept]
- calpain Lp82 [MeSH Supplementary Concept]
- calpain p94 [MeSH Supplementary Concept]
- capn3b protein, zebrafish [MeSH Supplementary Concept]
- m-calpain [MeSH Supplementary Concept]
- m-calpain proenzyme [MeSH Supplementary Concept]
- mu-calpain [MeSH Supplementary Concept]
- mu-calpain proenzyme [MeSH Supplementary Concept]
- procalpain [MeSH Supplementary Concept]
- sol protein, drosophila [MeSH Supplementary Concept]
- solh protein, mouse [MeSH Supplementary Concept]
See also (suggested by CISMeF)
- limb-girdle muscular dystrophy type 2A [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Calpain [NCIt concept]
- Calpain (substance) [SNOMED CT concept]
- calpain [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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