Preferred Label : calpain;
MeSH definition : Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins
including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC
MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium
sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase
kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly
listed as EC 3.4.22.4.;
MeSH synonym : calcium activated neutral protease; calcium-dependent neutral protease; protease, calcium-activated neutral; neutral proteinase, calcium-dependent; proteinase, calcium-dependent neutral; neutral proteinase, calcium-activated; calcium dependent neutral proteinase; calcium-activated neutral protease; calcium activated neutral proteinase; calcium activated protease; proteinase, calcium-activated neutral; protease, calcium-dependent neutral; desminase; neutral protease, calcium-dependent; calcium-activated neutral proteinase; calcium-dependent neutral proteinase; calcium-activated protease; protease, ca2 -activated; protease, calcium-activated; calcium dependent neutral protease; ca2 -activated protease; ca2 activated protease; neutral protease, calcium-activated;
CISMeF synonym : EC 3.4.22.-; I, calpain; II, calpain;
MeSH hyponym : calpain II; calpain I;
MeSH Related Number : calpain II; calpain I; EC 3.4.22.52; EC 3.4.22.53;
Registry Number MeSH : EC 3.4.22.-;
Related CAS MeSH : EC 3.4.22.53 (Calpain II); EC 3.4.22.52 (Calpain I);
MeSH annotation : /biosyn /physiol permitted;
Is substance : O;
Origin ID : D002154;
UMLS CUI : C0006784;
Allowable qualifiers
Automatic exact mappings (from CISMeF team)
Currated CISMeF NLP mapping
Indexing information
- AK 275 [MeSH Supplementary Concept]
- AK 295 [MeSH Supplementary Concept]
Record concept(s)
Related MeSH Supplementary Concept(s)
See also (suggested by CISMeF)
Semantic type(s)
UMLS correspondences (same concept)
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins
including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC
MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium
sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase
kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly
listed as EC 3.4.22.4.
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=267
France
French
muscular dystrophies, limb-girdle
rare diseases
calpain
limb-girdle muscular dystrophy type 2A
scientific and technical information
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