Preferred Label : GABA Receptor Life Cycle Pathway;
NCIt related terms : Gamma-aminobutyric Acid Receptor Life Cycle;
Alternative definition : BIOCARTA: Gamma-amino butyric acid (GABA) is an inhibitory neurotransmitter that acts
at synapses through binding to ligand-gated ion channels, the GABA receptors. Clustering
of the GABA-A receptor chloride channel alters receptor pharmacology on the cell surface
and reduced clustering of the GABA receptor is associated with anxiety. GABA-A interacts
with several proteins that modulate its clustering, endocytosis, and recycling or
degradation. Plic-1 is a ubiquitin-like protein that binds to GABA-A receptors and
causes them to accumulate at inhibitory synapses. Gephyrin interacts with the cytoplasmic
domain of GABA-A, and with microtubules, bringing receptors together in plasma microdomains.
Curiously, Gephyrin appears to be a bifunctional protein, with a domain involved in
molybdenum metabolism. Another protein interacting with the GABA-A receptor is GABARAP,
a microtubule-associated protein. Anchoring of the GABA-A receptor to GABARAP helps
to cluster the receptor at the synaptic termini and to mediate fast synaptic transmission.
GABARAP may mediate interaction of gephyrin with the GABA-A receptor and gephyrin
may stabilize clusters by forming multimeric structures. GABARAP and gephyrin may
play more of a role in receptor sorting and transport to the cell surface than in
anchoring to the cytoplasm, since at inhibitory synapses GABARAP appears to associate
with transport vesicles rather than the cell surface. The association of GABARAP with
NSF (N-ethyl maleimide sensitive factor), a protein involved in intracellular vesicle
transport, supports this hypothesis. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_gabaPathway;
Origin ID : C39089;
UMLS CUI : C1517351;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
