Preferred Label : Asunaprevir;
NCIt synonyms : ASV; 1,1-Dimethylethyl ((1S)-1-(((2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2- (((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-ethenylcyclopropyl)carbamoyl)
pyrrolidin-1-yl)carbonyl)-2,2-dimethylpropyl)carbamate;
NCIt definition : An orally bioavailable inhibitor of the nonstructural protein 3 (NS3), with potential
activity against hepatitis C virus (HCV). Upon administration, asunaprevir binds to
the active center of the HCV NS3 and prevents NS3 protease-mediated polyprotein maturation.
This disrupts the processing of viral proteins required for HCV replication. NS3,
a serine protease, is essential for the proteolytic cleavages within the HCV polyprotein
and plays a key role during HCV viral RNA replication. HCV is a small, enveloped,
single-stranded RNA virus belonging to the Flaviviridae family.;
UNII : S9X0KRJ00S;
InChIKey : XRWSZZJLZRKHHD-WVWIJVSJSA-N;
CAS number : 630420-16-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 630420-16-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : BMS-650032;
Origin ID : C114982;
UMLS CUI : C3491974;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
https://www.has-sante.fr/jcms/p_3474308/en/aircurve-11-asv-pacewave
2023
France
health technology assessment
SRC wt Allele
ventilation
ventilation, nos
Drug Delivery System
Enslavement
Ventilation
Neoantigen-HSP70 Peptide Cancer Vaccine AGEN2017
Theophylline
Asunaprevir
Device System
Drug Delivery System Category
Eleven
Loss of Chromosome 11
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