Asunaprevir - CISMeF

Preferred Label : Asunaprevir;

NCIt synonyms : ASV; 1,1-Dimethylethyl ((1S)-1-(((2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2- (((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-ethenylcyclopropyl)carbamoyl) pyrrolidin-1-yl)carbonyl)-2,2-dimethylpropyl)carbamate;

NCIt definition : An orally bioavailable inhibitor of the nonstructural protein 3 (NS3), with potential activity against hepatitis C virus (HCV). Upon administration, asunaprevir binds to the active center of the HCV NS3 and prevents NS3 protease-mediated polyprotein maturation. This disrupts the processing of viral proteins required for HCV replication. NS3, a serine protease, is essential for the proteolytic cleavages within the HCV polyprotein and plays a key role during HCV viral RNA replication. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family.;

UNII : S9X0KRJ00S;

InChIKey : XRWSZZJLZRKHHD-WVWIJVSJSA-N;

CAS number : 630420-16-5;

Molecule name : BMS-650032;

Details

Origin ID

C114982;

UMLS CUI

C3491974;

Automatic exact mappings (from CISMeF team)
- Asunaprevir [ICD-11 Extension code]
- Asunaprevir (substance) [SNOMED CT concept]
- SRC proto-oncogene, non-receptor tyrosine kinase [ORDO Gene]
- Src protooncogene, nonreceptor tyrosine kinase [OMIM gene]
- asunaprevir [MeSH concept]
- asunaprevir [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Asunaprevir (substance) [SNOMED CT concept]
- asunaprevir [ATC Code]
- asunaprevir [MeSH Supplementary Concept]
- asunaprevir [MeSH concept]
Validated automatic mappings to BTNT
- asunaprevir [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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