NCIt synonyms : TGF B Receptor; Transforming Growth Factor Beta Receptor; TGFBR2; TGF-Beta Type II Receptor; TGF-Beta Receptor Type II; Transforming Growth Factor Beta Receptor II; EC 2.7.11.30; TGFR-2; TbetaR-II;
NCIt definition : TGF-beta receptor type-2 (567 aa, 65 kDa) is encoded by the human TGFBR2 gene. This
protein plays a role in both serine/threonine phosphorylation and TGF-beta-mediated
signal transduction.;
NCIt note : There are three TGF-beta receptors, Type I and Type II together form a heterodimeric
signaling complex that is essential for the transduction of the anti-proliferative
signals of TGF-beta. Type III is a transmembrane proteoglycan with a large extracellular
domain and a cytoplasmic domain that lacks an obvious signaling motif.;