TGF-Beta Receptor Type-2

Preferred Label : TGF-Beta Receptor Type-2;

NCIt synonyms : TGF B Receptor; Transforming Growth Factor-Beta Receptor 2; TGFBR2; TGF-Beta Type II Receptor; TGF-Beta Receptor Type II; Transforming Growth Factor Beta Receptor II; EC 2.7.11.30; TGFR-2; TbetaR-II; Transforming Growth Factor Beta Receptor 2; Transforming Growth Factor-Beta Receptor II;

NCIt definition : TGF-beta receptor type-2 (567 aa, 65 kDa) is encoded by the human TGFBR2 gene. This protein plays a role in both serine/threonine phosphorylation and TGF-beta-mediated signal transduction.;

NCIt note : There are three TGF-beta receptors, Type I and Type II together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. Type III is a transmembrane proteoglycan with a large extracellular domain and a cytoplasmic domain that lacks an obvious signaling motif.;

Détails

Origin ID

C17341;

UMLS CUI

C1506219;

Currated CISMeF NLP mapping
- receptors, transforming growth factor beta [MeSH Descriptor]
- receptors, transforming growth factor beta [MeSH concept]
OMIM relation
- Transforming growth factor-beta receptor, type II [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TGFBR2 protein, human [MeSH Supplementary Concept]
- TGFBR2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Pediatric Oncology Biomarkers/Targets Associated with Other Relevant Evidence [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Serine/Threonine Kinase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- TGFBR2 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- ALK Pathway [NCIt concept]
- Adherens Junction Assembly Pathway [NCIt concept]
- CTCF Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Glypican 1 Signaling Pathway [NCIt concept]
- Hippo Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- NFKB Activation Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- TGF Beta Signaling Pathway BioCarta [NCIt concept]
- TGF-Beta Receptor Signaling Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
gene_product_malfunction_associated_with_disease
- Lynch Syndrome [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumor Suppression [NCIt concept]
has_gene_product_element
- Endoglin [NCIt concept]
is_target
- Anti-TGF-beta RII Monoclonal Antibody IMC-TR1 [NCIt concept]

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