Mothers Against Decapentaplegic Homolog 2

Preferred Label : Mothers Against Decapentaplegic Homolog 2;

NCIt synonyms : MADH2; SMA- and MAD-Related Protein 2; Mothers Against Decapentaplegic, Drosophila, Homolog 2 Protein; MAD, Mothers Against Decapentaplegic Homolog 2 Protein; hMAD-2; MAD-Related Protein 2; MAD (Mothers Against Decapentaplegic, Drosophila) Homolog 2 Protein; JV18-1; Mothers Against DPP Homolog 2 Protein; hSMAD2; Mothers Against Decapentaplegic Homolog 2 Protein; Mothers Against DPP Homolog 2; SMAD2; SMAD Family Member 2; SMAD2 Protein; MAD Homolog 2;

NCIt definition : Mothers against decapentaplegic homolog 2 (467 aa, 52 kDa) is encoded by the human SMAD2 gene. This protein plays a role in signal transduction and transcriptional regulation.;

NCIt note : Retained by cytoplasmic SARA, SMAD2/SMAD3 are phosphorylated on conserved C-terminal MH2 docking SER-X-SERs by activated receptor. SMAD2/SMAD3 oligomerize with nuclear SMAD4, disrupting SNON/SMAD4 repressors. SMAD3 causes SNON degradation. SMAD2/SMAD4 activate target promoters. TGFBR activity maintains nuclear SMADs and increases feedback SNON expression. SMAD2 interacts with FAST-1/-2, TGIF, PEBP2-A, CBP, p300, c-SKI, NUP214, NUP153, and SMURF2. MADR2 mutations may disrupt growth inhibition. (from LocusLink, Swiss-Prot, OMIM);

Details

Origin ID

C26480;

UMLS CUI

C1566790;

Currated CISMeF NLP mapping
- Smad2 protein [MeSH concept]
- smad2 protein [MeSH Descriptor]
OMIM relation
- Smad family member 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
UMLS correspondences (same concept)
- SMAD2 protein, human [MeSH Supplementary Concept]
- SMAD2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- SMAD2 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Adherens Junction Assembly Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Glypican 1 Signaling Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Regulation of Cytoplasmic and Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- TGF Beta Signaling Pathway BioCarta [NCIt concept]
- TGF-Beta Receptor Signaling Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- DNA Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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