Tyrosine-Protein Phosphatase Non-Receptor Type 1

Preferred Label : Tyrosine-Protein Phosphatase Non-Receptor Type 1;

NCIt synonyms : PTPN1; PTP-1B; Protein-Tyrosine Phosphatase 1B; Protein Tyrosine Phosphatase, Non-Receptor Type 1; EC 3.1.3.48; Non-Receptor Type 1 Protein Tyrosine Phosphatase;

NCIt definition : Tyrosine-protein phosphatase non-receptor type 1 (435 aa, 50 kDa) is encoded by the human PTPN1 gene. This protein plays a role in endocytosis, the unfolded protein response, signaling and protein dephosphorylation.;

NCIt note : PTPN1 may dephosphorylate EGFR kinase, as well as JAK2 and TYK2 kinases, suggesting a role in cell growth control, and cell response to interferon stimulation. Oxidation of Cys-215 forms a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity; the active site is restored by reduction. (UniProt);

Details

Origin ID

C26339;

UMLS CUI

C1335056;

Automatic exact mappings (from CISMeF team)
- Protein-tyrosine phosphatase, nonreceptor-type, 1 [OMIM gene]
- protein tyrosine phosphatase non-receptor type 1 [HGNC gene]
Currated CISMeF NLP mapping
- protein tyrosine phosphatase, Non-Receptor type 1 [MeSH Descriptor]
- protein tyrosine phosphatase, Non-Receptor type 1 [MeSH concept]
OMIM relation
- Protein-tyrosine phosphatase, nonreceptor-type, 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PTPN1 protein, human [MeSH concept]
- PTPN1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Non-Receptor Protein Tyrosine Phosphatase Gene [NCIt concept]
- PTPN1 Gene [NCIt concept]
- Phosphatase Family Gene [NCIt concept]
- Protein Phosphatase Gene [NCIt concept]
- Protein Tyrosine Phosphatase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- PTB Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adherens Junction Assembly Pathway [NCIt concept]
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway PID [NCIt concept]
- IGF1 Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- N-Cadherin Signaling Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- PTPN1 Signaling Pathway [NCIt concept]
- Phosphatidylinositol Signaling System Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Dephosphorylation [NCIt concept]
- Hydrolysis [NCIt concept]
- Protein Dephosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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