Preferred Label : PTPN2/1 Inhibitor ABBV-CLS-579;
NCIt synonyms : PTPN2/N1 Inhibitor ABBV-CLS-579; PTPN1/2 Inhibitor ABBV-CLS-579; PTPN1/PTPN2 Inhibitor ABBV-CLS-579;
NCIt definition : An orally bioavailable inhibitor of protein tyrosine phosphatase (PTP) non-receptor
type 2 (PTPN2; T-cell protein tyrosine phosphatase; TCPTP) and type 1 (PTPN1; PTP1B),
with potential immunomodulating and antineoplastic activities. Upon oral administration,
PTPN2/1 inhibitor ABBV-CLS-579 targets, binds to and inhibits the activity of PTPN2
and PTPN1. This prevents PTPN2/1-mediated signaling and prevents PTPN2/1-mediated
negative regulation of immune response pathways. This may promote antitumor immune
responses by increasing the activation and function of certain immune cells, including
T-cells and dendritic cells (DCs), inducing cytokine production, and enhancing interferon
gamma (IFNg)-mediated tumor growth arrest. PTPN1 and PTPN2, members of the PTP superfamily,
are intracellular T-cell checkpoints and negative regulators of several cytokine signaling
pathways and T-cell receptor (TCR) signaling. They play key roles in tumor immune
suppression and tumor growth.;
Molecule name : ABBV-CLS 579; ABBV-CLS-579;
Origin ID : C217651;
concept_is_in_subset
- has_target
