Preferred Label : Osunprotafib;
NCIt synonyms : PTPN2 Inhibitor ABBV-CLS-484;
NCIt definition : An orally bioavailable inhibitor of the T-cell specific tyrosine-protein phosphatase
non-receptor type 2 (PTPN2), with potential immunomodulating and antineoplastic activities.
Upon oral administration, osunprotafib specifically targets and binds to PTPN2. This
prevents PTPN2-mediated signal transduction pathways and may activate anti-tumor T-cell
immune responses. It may also sensitize tumor cells to immunotherapeutics. PTPN2 negatively
regulates TCR and cytokine signaling needed for T cell function, homeostasis and differentiation.;
UNII : 82TTG6WR6B;
CAS number : 2489404-97-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2489404-97-7
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : ABBV CLS-484; ABBV CLS 484;
NCI Metathesaurus CUI : CL1662460;
Origin ID : C179723;
UMLS CUI : C5555877;
Semantic type(s)
- concept_is_in_subset
- has_target
