NCIt definition : An orally bioavailable inhibitor of the T-cell specific tyrosine-protein phosphatase
non-receptor type 2 (PTPN2), with potential immunomodulating and antineoplastic activities.
Upon oral administration, osunprotafib specifically targets and binds to PTPN2. This
prevents PTPN2-mediated signal transduction pathways and may activate anti-tumor T-cell
immune responses. It may also sensitize tumor cells to immunotherapeutics. PTPN2 negatively
regulates TCR and cytokine signaling needed for T cell function, homeostasis and differentiation.;
Semantic type(s)