Mothers Against Decapentaplegic Homolog 4

Preferred Label : Mothers Against Decapentaplegic Homolog 4;

NCIt synonyms : MADH4; MAX-Interacting Transcriptional Repressor; DPC4 Protein; SMAD4 Protein; SMA- and MAD-Related Protein 4; MAD4; SMAD Family Member 4; Smad4; hSMAD4; Mothers Against Decapentaplegic Homolog-4 Protein; Mothers Against DPP Homolog 4; Deletion Target in Pancreatic Carcinoma 4; MAD Homolog 4; SMAD 4;

NCIt definition : Mothers against decapentaplegic homolog 4 (552 aa, 60 kDa) is encoded by the human SMAD4 gene. This protein is involved in cytokine signaling and transcription factor activity.;

NCIt note : Mothers against decapentaplegic homolog 4 binds to the DNA consensus sequence 5'-GTCTAGAC-3' called the Smad-binding element (SBE).;

Details

Origin ID

C17982;

UMLS CUI

C0385939;

Currated CISMeF NLP mapping
- Smad4 protein [MeSH concept]
- smad4 protein [MeSH Descriptor]
OMIM relation
- Smad family member 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SMAD4 protein, human [MeSH Supplementary Concept]
- SMAD4 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- SMAD4 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
- Transcription Coactivator [NCIt concept]
gene_product_is_element_in_pathway
- ALK Pathway [NCIt concept]
- Adherens Junction Assembly Pathway [NCIt concept]
- CTCF Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- NFKB Activation Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- T-Cell Activation Pathway [NCIt concept]
- TGF Beta Signaling Pathway BioCarta [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
- WNT Signaling Pathway BioCarta [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
gene_product_malfunction_associated_with_disease
- Juvenile Polyposis Syndrome [NCIt concept]
- Malignant Colon Neoplasm [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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