Preferred Label : Transcription Factor 7-Like 2;
NCIt synonyms : TCF7L2; TCF4; T-Cell-Specific Transcription Factor 4; HMG Box Transcription Factor 4; hTCF4; hTCF-4; T-Cell Factor 4; TCF-4; Transcription Factor-7-Like-2 Protein;
NCIt definition : Transcription factor 7-like 2 (619 aa, 68 kDa) is encoded by the human TCF7L2 gene.
This protein is involved in the positive regulation of transcription, cell cycle arrest,
apoptosis regulation, cell and tissue differentiation and signal transduction.;
NCIt note : Transcription Factor 7-Like 2, participates in the WNT pathway and maintains epithelial
stem cells of the small intestine. Absent CTNNB1, TCF7L2 acts as a repressor. Bound
to the CTNNB1 armadillo repeat in a stable complex, TCF7L2 activates transcription
from promoters containing the TCF motif (CCTTTGATC). TCF7L2 binds to the MYC promoter
in a sequence-specific manner and modulates MYC expression. The TCF7L2 activation
domain binds transcriptional coactivator EP300. TLE1, TLE2, TLE3, and TLE4 repress
TCF7L2/CTNNB1 mediated transactivation. Constitutive TCF7L2 activation may promote
maintenance of the stem cell phenotype and initiate colorectal cancer. TCF7L2/CTNNB1
may control proliferation versus differentiation in intestinal epithelial cells.;
Origin ID : C30080;
UMLS CUI : C1336781;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
