Preferred Label : TGFbeta Inhibitor LY3200882;
NCIt synonyms : TGFb Inhibitor LY 3200882;
NCIt related terms : LY-3200882;
NCIt definition : An orally bioavailable agent that targets transforming growth factor-beta (TGFb),
with potential antineoplastic activity. Upon administration, LY3200882 specifically
targets and binds to TGFb, which prevents both the binding of TGFb to its receptor
TGFbR and TGFb-mediated signal transduction. This may lead to a reduction in TGFb-dependent
proliferation of cancer cells. The TGFb signaling pathway is often deregulated in
tumors, and plays a key role in the regulation of cell growth, differentiation, apoptosis,
motility, invasion, angiogenesis, and various immune responses.;
UNII : 19HY34R6UN;
CAS number : 1898283-02-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1898283-02-7
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G-SRS /a ;
Molecule name : LY 3200882; LY3200882;
NCI Metathesaurus CUI : CL520999;
Origin ID : C132013;
UMLS CUI : C4331372;
Semantic type(s)
- concept_is_in_subset
- has_target
