Preferred Label : TGF-beta Receptor 1 Inhibitor GFH018;
NCIt synonyms : Transforming Growth Factor-beta Receptor 1 Inhibitor GFH018; TGFbR1 Inhibitor GFH018;
NCIt definition : An orally bioavailable inhibitor of transforming growth factor-beta receptor 1 (TGFbR1),
with potential antineoplastic activity. Upon oral administration, TGFbR1 inhibitor
GFH018 specifically targets and binds to TGFbR1, which prevents TGFbR1-mediated signal
transduction. This abrogates TGFbR1-mediated immunosuppression, enhances anti-tumor
immunity in the tumor microenvironment (TME) and promotes a cytotoxic T-lymphocyte
(CTL)-mediated immune response against tumor cells leading to tumor cell death. This
may lead to a reduction in TGFbR1-dependent proliferation of cancer cells. The TGFb
signaling pathway is often deregulated in tumors and plays a key role in the regulation
of cell growth, differentiation, apoptosis, motility, invasion, and angiogenesis.
It plays a key role in immunosuppression in the TME.;
Molecule name : GFH-018; GFH 018;
NCI Metathesaurus CUI : CL1663610;
Origin ID : C181021;
UMLS CUI : C5556786;
Semantic type(s)
- concept_is_in_subset
- has_target
