Transforming Growth Factor Beta Receptor Type 3

Preferred Label : Transforming Growth Factor Beta Receptor Type 3;

NCIt synonyms : Beta-Glycan; TGFR3; Transforming Growth Factor Beta Receptor Type III; TGF-Beta Receptor Type III; Betaglycan; Transforming Growth Factor Beta Receptor-III; TGF-Beta Receptor Type 3; Transforming Growth Factor Beta Receptor III; TGFR-3; Betaglycan Proteoglycan; TGFBR3; Transforming Growth Factor Beta Receptor 3;

NCIt definition : Transforming growth factor beta receptor type 3 (851 aa, 93 kDa) is encoded by the human TGFBR3 gene. This protein is involved in TGF-beta binding.;

NCIt note : TGFBR3 binds to TGF-Beta and may be a TGFBR and FGFR receptor accessory molecule; it may capture and retain TGF-Beta for presentation to signaling receptors. TGFBR3 can also bind inhibin and function as coreceptor with ActRII; inhibin forms crosslinked complexes with TGFBR3 and ActRII. TGFBR3 also binds beta arrestin 2, which appears to trigger cytoplasmic phosphorylation by TGFBR2.; There are three TGF-beta receptors, Type I and Type II together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. Type III is a transmembrane proteoglycan with a large extracellular domain and a cytoplasmic domain that lacks an obvious signaling motif.;

Details

Origin ID

C30099;

UMLS CUI

C1700222;

Currated CISMeF NLP mapping
- Betaglycan [FMA entity]
- betaglycan [MeSH concept]
- betaglycan [MeSH Supplementary Concept]
OMIM relation
- Transforming growth factor-beta receptor, type III [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- Betaglycan [FMA entity]
- TGFBR3 protein, human [MeSH concept]
- betaglycan [MeSH Supplementary Concept]
- betaglycan [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Serine/Threonine Kinase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- TGFBR3 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- ALK Pathway [NCIt concept]
- CTCF Pathway [NCIt concept]
- T-Cell Activation Pathway [NCIt concept]
- TGF-Beta Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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