NCIt definition : An orally available inhibitor of the mammalian target of rapamycin (mTOR) with potential
antineoplastic activity. Onatasertib inhibits the activity of mTOR, which may result
in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation.
mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays
an important role downstream in the PI3K/AKT/mTOR signaling pathway, which is frequently
dysregulated in human cancers.;
UNII : I8RA3543SY;
InChIKey : UFKLYTOEMRFKAD-SHTZXODSSA-N;
CAS number : 1228013-30-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1228013-30-6
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G-SRS /a ;
Semantic type(s)