Preferred Label : Everolimus;
NCIt synonyms : 42-O-(2-Hydroxy)ethyl Rapamycin; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone;
NCIt related terms : RAD001; Afinitor;
NCIt definition : A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and
anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding
Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits
the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase.
Inhibition of mTOR activation results in the inhibition of T lymphocyte activation
and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation
and the inhibition of antibody production. (NCI05);
Alternative definition : NCI-GLOSS: A drug used to treat advanced kidney cancer that did not respond to treatment
with certain other anticancer drugs. It is also being studied in the treatment of
other types of cancer. Afinitor stops cancer cells from dividing and may block the
growth of new blood vessels that tumors need to grow. It also decreases the body's
immune responses. It is a type of immunosuppressant and a type of antiangiogenesis
agent.;
UNII : 9HW64Q8G6G;
InChIKey : HKVAMNSJSFKALM-GKUWKFKPSA-N;
CAS number : 159351-69-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 159351-69-6
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G-SRS /a ;
Drug name : Certican; Afinitor; Zortress; Votubia;
Molecule name : RAD 001; RAD-001;
Chemical formula : C53H83NO14;
NSC code : 733504;
Codes from synonyms : CDR0000386203; CDR0000639748; CDR0000639749; 50567; 202;
Origin ID : C48387;
UMLS CUI : C0541315;
CISMeF manual mappings
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
