Preferred Label : PI3K Alpha/mTOR Inhibitor PWT33597 Mesylate;
NCIt definition : The mesylate salt form of PWT33597, an orally bioavailable dual inhibitor of phosphatidylinositide
3-kinase (PI3K) alpha and mammalian target of rapamycin (mTOR) kinase with potential
antineoplastic activity. PI3K alpha/mTOR dual inhibitor PWT33597 selectively inhibits
both PI3K alpha kinase and mTOR kinase, which may result in tumor cell apoptosis and
growth inhibition in PI3K/mTOR-overexpressing tumor cells. Activation of the PI3K/mTOR
pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy;
mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent
of PI3K.;
Molecule name : PWT33597 Mesylate;
NCI Metathesaurus CUI : CL430398;
Origin ID : C97915;
UMLS CUI : C3273693;
Semantic type(s)
- concept_is_in_subset
- has_target
