Stat3 Signaling Pathway

Preferred Label : Stat3 Signaling Pathway;

Alternative definition : BIOCARTA: STATs, Signal Transducers and Activators of Transcription, are transcription factors that are phosphorylated by JAK kinases in response to cytokine activation to dimerize and move into the nucleus to activate transcription of cytokine-responsive genes. There are at least 3 JAK kinases and at least six STATs, with different cytokines inducing different patterns of JAK and STAT activation. Cytokines that activate STAT3 include growth hormone, IL-6 family cytokines, and G-CSF. STAT3, as well as STAT5, induces progression through the cell cycle, prevents apoptosis, and may be associated with cancer development in some cases. STAT3 plays an important role in normal development, particularly hematopoiesis. The importance of STAT3 is underscored by the failure of mice lacking STAT3 to survive embryogenesis. Crosstalk from pathways other than JAK kinases also leads to phosphorylation and activation of STAT3 as indicated by a role of mTOR (mammalian target of rapamycin, or p70 S6 kinase) and mitogen-activated protein kinase (MAP kinase) pathways in STAT3 activation and signaling. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_stat3Pathway;

Details

Origin ID

C39238;

UMLS CUI

C1514955;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Non-Receptor Tyrosine-Protein Kinase TYK2 [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
- Signal Transducer and Activator of Transcription 3 [NCIt concept]
- Tyrosine-Protein Kinase JAK1 [NCIt concept]
- Tyrosine-Protein Kinase JAK3 [NCIt concept]
pathway_has_gene_element
- JAK1 wt Allele [NCIt concept]
- JAK2 wt Allele [NCIt concept]
- JAK3 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MTOR wt Allele [NCIt concept]
- STAT3 wt Allele [NCIt concept]
- TYK2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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