Ridaforolimus - CISMeF

Preferred Label : Ridaforolimus;

NCIt synonyms : Rapamycin, 42-(dimethylphosphinate); Deforolimus;

NCIt related terms : AP23573;

NCIt definition : A small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of soft tissue and bone cancers. It is also being studied in the treatment of other solid tumors and hematologic cancer. Ridaforolimus stops cells from dividing and may cause cancer cells to die. It is a type of mTOR inhibitor.;

UNII : 48Z35KB15K;

InChIKey : BUROJSBIWGDYCN-GAUTUEMISA-N;

CAS number : 572924-54-0;

Molecule name : MK-8669; AP23573;

Chemical formula : C53H84NO14P;

Codes from synonyms : CDR0000642130; CDR0000446800;

Details

Origin ID

C49061;

UMLS CUI

C2713007;

Automatic exact mappings (from CISMeF team)
- Ridaforolimus [ICD-11 Extension code]
- ridaforolimus [ATC Code]
Currated CISMeF NLP mapping
- ridaforolimus [MeSH concept]
- ridaforolimus [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ridaforolimus [ATC Code]
- ridaforolimus [MeSH concept]
- ridaforolimus [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]

Keyword's position in hierarchy(ies) :

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