Preferred Label : PI3K/mTOR Inhibitor CLL442;
NCIt definition : A topical inhibitor of class I phosphoinositide 3-kinase (PI3K) isoforms and mammalian
target of rapamycin kinase (mTOR), with potential antineoplastic activity. Upon topical
administration, PI3K/mTOR inhibitor CLL442 targets and inhibits class I PI3K isoforms
and mTOR kinase. This disrupts phosphorylation of substrates downstream of PI3K and
mTOR and may result in apoptosis and growth inhibition in susceptible tumor cells.
The PI3K/mTOR pathway is upregulated in a variety of tumor cells and plays a key role
in promoting cancer cell proliferation, survival and motility.;
Molecule name : CLL 442; CLL-442;
NCI Metathesaurus CUI : CL1905421;
Origin ID : C191957;
UMLS CUI : C4733659;
Semantic type(s)
- concept_is_in_subset
- has_target
