pan-PI3K/mTOR Inhibitor SF1126

Preferred Label : pan-PI3K/mTOR Inhibitor SF1126;

NCIt related terms : SF-1126;

NCIt definition : A water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival.;

UNII : DL0Q912033;

InChIKey : SVNJBEMPMKWDCO-KCHLEUMXSA-N;

CAS number : 936487-67-1;

Molecule name : SF1126;

Details

Origin ID

C85469;

UMLS CUI

C2351370;

Currated CISMeF NLP mapping
- SF 1126 [MeSH Supplementary Concept]
- SF 1126 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SF 1126 [MeSH concept]
- SF 1126 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]

Keyword's position in hierarchy(ies) :

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