" /> pan-PI3K/mTOR Inhibitor SF1126 - CISMeF





Preferred Label : pan-PI3K/mTOR Inhibitor SF1126;

NCIt related terms : SF-1126;

NCIt definition : A water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival.;

UNII : DL0Q912033;

InChIKey : SVNJBEMPMKWDCO-KCHLEUMXSA-N;

CAS number : 936487-67-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 936487-67-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SF1126;

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15/05/2024


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