Mechanistic Target of Rapamycin Complex 1

Preferred Label : Mechanistic Target of Rapamycin Complex 1;

MeSH definition : An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.;

MeSH synonym : mTORC1; mTORC1 Complex; Complex, mTORC1; TORC1; TOR Complex 1; Target of Rapamycin Complex 1;

Registry Number MeSH : EC 2.7.11.1;

UNII : EC 2.7.11.1;

Details

Origin ID

D000076222;

UMLS CUI

C3888046;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- CREB-Regulated Transcription Coactivator 1 [NCIt concept]
- CRTC1 wt Allele [NCIt concept]
- Creb-regulated transcription coactivator 1 [OMIM gene]
- Mechanistic target of rapamycin [OMIM gene]
- TORC1 complex [GO term]
- mTORC1 [NCIt concept]
Record concept(s)
- mechanistic target of rapamycin complex 1 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- mTORC1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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