" /> Ku Protein - CISMeF





Preferred Label : Ku Protein;

NCIt synonyms : ATP-Dependent DNA Helicase 2; La Protein; ATP-Dependent DNA Helicase II; Lupus Autoantigen; Lupus Ku Autoantigen; DNA Helicase II Complex; TLAA; Thyroid-Lupus Autoantigen; Ku; CTCBF;

NCIt related terms : Ku Autoantigen; KU ANTIGEN;

NCIt definition : A DNA damage repair complex that, with the 470-kDa DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein, is part of the DNA-dependent protein kinase. This protein complex is involved in V(D)J recombination, nonhomologous end-joining DNA repair, and the recognition and repair of double-stranded DNA breaks.;

Alternative definition : CDISC: A heterodimer (Ku70/Ku80) DNA-binding nuclear protein that is involved in nonhomologous end-joining DNA repair, and the recognition and repair of double-stranded DNA breaks. It can be considered as an autoantigen and is commonly associated with autoimmune connective tissue diseases and systemic sclerosis.;

NCIt note : Eukaryotic Ku is a heterodimer of two polypeptides, X-ray repair cross-complementing protein 6 (Ku70) and X-ray repair cross-complementing protein 5 (Ku80).;

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11/05/2024


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