Ku Autoantigen

Preferred Label : Ku Autoantigen;

MeSH definition : An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.;

MeSH synonym : Autoantigen, Ku; Ku Heterodimer; Heterodimer, Ku; Ku Protein; Ku Antigen; Antigen, Ku; G22P1 Antigen; Antigen, G22P1;

DeCS synonym : Ku70 Antigen; Ku80 Antigen;

MeSH hyponym : Antigen, Ku80; Ku Autoantigen, 80 kDa; XRCC5 Protein; X-ray Repair Cross-Complementing Protein 5; X ray Repair Cross Complementing Protein 5; Antigen, Ku70; Ku Autoantigen, 70 kDa; XRCC6 Protein; X-ray Repair Cross-Complementing Protein 6; X ray Repair Cross Complementing Protein 6;

MeSH Related Number : EC 3.6.4.12;

Registry Number MeSH : EC 4.2.99.-;

Wikipedia link : https://en.wikipedia.org/wiki/Ku protein;

Details

Origin ID

D000072200;

UMLS CUI

C0124761;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- X-Ray Repair Cross-Complementing Protein 5 [NCIt concept]
- X-Ray Repair Cross-Complementing Protein 6 [NCIt concept]
- X-ray repair cross complementing 5 [HGNC gene]
- X-ray repair cross complementing 6 [HGNC gene]
Currated CISMeF NLP mapping
- Blood group antigen Ku (substance) [SNOMED CT concept]
- blood group antigen ku [SNOMED Notion]
False automatic mappings
- Ku Protein [NCIt concept]
Record concept(s)
- Ku70 antigen [MeSH concept]
- Ku80 antigen [MeSH concept]
- ku autoantigen [MeSH concept]
Related MeSH Supplementary Concept(s)
- XRCC5 protein, human [MeSH Supplementary Concept]
- Xrcc5 protein, mouse [MeSH Supplementary Concept]
- Xrcc5 protein, rat [MeSH Supplementary Concept]
- Xrcc6 protein, human [MeSH Supplementary Concept]
- Xrcc6 protein, mouse [MeSH Supplementary Concept]
- Xrcc6 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Blood group antigen Ku (substance) [SNOMED CT concept]
- blood group antigen ku [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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