Helicase - CISMeF

Preferred Label : Helicase;

NCIt synonyms : Helicases;

NCIt definition : Helicases are a class of enzymes that utilize the energy of ATP hydrolysis to promote unwinding of 1.) RNA during transcription, splicing and translation or 2.) duplex DNA during replication or repair by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening.;

NCI Metathesaurus CUI : CL448382;

Details

Origin ID

C20423;

UMLS CUI

C0920283;

Biochemical function of gene products
- DNA Repair and Recombination Protein RAD54B [NCIt concept]
- Ku Protein [NCIt concept]
- X-Ray Repair Cross-Complementing Protein 6 [NCIt concept]
Currated CISMeF NLP mapping
- DNA helicases [MeSH Descriptor]
- DNA helicases [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- DNA helicases [MeSH Descriptor]
- DNA helicases [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Helicase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- Hydrolysis [NCIt concept]
- Nucleic Acid Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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