NCIt definition : Human RAG2 wild-type allele is located in the vicinity of 11p13 and is approximately
6 kb in length. This allele, which encodes V(D)J recombination-activating protein
2, is involved in the regulation of immunoglobulin recombination. Mutation of the
gene is associated with several hereditary immunodeficiencies. Genetic variation may
be associated with the relapse of acute lymphoblastic leukemia.;
NCIt note : Mutations in the RAG2 gene are associated with combined cellular and humoral immune
defects with granulomas, severe combined immunodeficiency, and Omenn syndrome. (UniProt);