Preferred Label : High Mobility Group Protein B1;
NCIt synonyms : High-Mobility Group Box 1; HMG 1; Nonhistone Chromosomal Protein HGM1; High Mobility Group Protein 1; Amphoterin; HMG-1; Chromosomal Protein, Nonhistone, HMG1; SBP-1; High-Mobility Group (Nonhistone Chromosomal) Protein 1; HMGB1; HMG3; Sulfoglucuronyl Carbohydrate Binding Protein; HMG1;
CISMeF acronym : HMGB1;
NCIt definition : High mobility group protein B1 (215 aa, 25 kDa) is encoded by the human HMGB1 gene.
This protein is involved in the regulation of both chromatin structure and DNA topology.;
NCIt note : HMGB1 is a very abundant and conserved 25-kD protein which plays a central role in
the stabilization and/or assembly of several nucleoprotein multifunctional complexes
through protein-protein interactions. HMGB1 is essential in a variety of DNA-related
biological processes, e.g., V(D)J recombination, the initiation of transcription,
and DNA repair. HMGB1 binds DNA without sequence specificity, but has a high affinity
for bent or distorted DNA, and bend linear DNA. HMGB1 interacts with many apparently
unrelated proteins by recognizing short amino acid sequences. HMGB1 is structured
into two DNA-binding HMG-box domains (A and B) plus a long highly acidic C-terminal
domain. The individual A and B boxes exhibit many of the structure-specific properties
of the whole protein and the acidic tail modulates the affinity of the tandem HMG
boxes in HMGB1 for a variety of DNA targets. (PMID 11497996, PMID 11748221);
Origin ID : C20328;
UMLS CUI : C3710671;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
- is_target
