Base Excision Repair Pathway

Preferred Label : Base Excision Repair Pathway;

NCIt related terms : Base excision repair;

Alternative definition : KEGG: Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.;

KEGG ID : hsa03410;

Details

Origin ID

C91457;

UMLS CUI

C2984269;

Automatic exact mappings (from CISMeF team)
- base-excision repair [GO term]
- dna repair [MeSH Descriptor]
See also inter- (CISMeF)
- base excision repair [MeSH concept]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Adenine DNA Glycosylase [NCIt concept]
- DNA Ligase 3 [NCIt concept]
- DNA Polymerase Beta [NCIt concept]
- DNA Polymerase Delta Catalytic Subunit [NCIt concept]
- DNA Polymerase Delta Subunit 3 [NCIt concept]
- DNA Polymerase Epsilon Catalytic Subunit A [NCIt concept]
- DNA Polymerase Epsilon Subunit 2 [NCIt concept]
- DNA Repair Protein XRCC1 [NCIt concept]
- DNA-(Apurinic or Apyrimidinic Site) Lyase [NCIt concept]
- DNA-3-Methyladenine Glycosylase [NCIt concept]
- Endonuclease 8-Like 1 [NCIt concept]
- Endonuclease 8-Like 3 [NCIt concept]
- Endonuclease III-Like Protein 1 [NCIt concept]
- Flap Endonuclease 1 [NCIt concept]
- G/T Mismatch-Specific Thymine DNA Glycosylase [NCIt concept]
- High Mobility Group Protein B1 [NCIt concept]
- Methyl-CpG-Binding Domain Protein 4 [NCIt concept]
- N-Glycosylase/DNA Lyase [NCIt concept]
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
- Poly [ADP-Ribose] Polymerase 2 [NCIt concept]
- Poly(ADP-Ribose) Glycohydrolase [NCIt concept]
- Protein Mono-ADP-Ribosyltransferase PARP3 [NCIt concept]
- Single-Strand Selective Monofunctional Uracil DNA Glycosylase [NCIt concept]
- Uracil-DNA Glycosylase [NCIt concept]
- Uracil-DNA Glycosylase Isoform 1 [NCIt concept]
pathway_has_gene_element
- APEX1 wt Allele [NCIt concept]
- APEX2 wt Allele [NCIt concept]
- FEN1 wt Allele [NCIt concept]
- HMGB1 wt Allele [NCIt concept]
- LIG3 wt Allele [NCIt concept]
- MBD4 wt Allele [NCIt concept]
- MPG wt Allele [NCIt concept]
- MUTYH wt Allele [NCIt concept]
- NEIL1 wt Allele [NCIt concept]
- NEIL3 wt Allele [NCIt concept]
- NTHL1 wt Allele [NCIt concept]
- OGG1 wt Allele [NCIt concept]
- PARG wt Allele [NCIt concept]
- PARP1 wt Allele [NCIt concept]
- PARP2 wt Allele [NCIt concept]
- PARP3 wt Allele [NCIt concept]
- POLB wt Allele [NCIt concept]
- POLD1 wt Allele [NCIt concept]
- POLD3 wt Allele [NCIt concept]
- POLE wt Allele [NCIt concept]
- POLE2 wt Allele [NCIt concept]
- SMUG1 wt Allele [NCIt concept]
- TDG wt Allele [NCIt concept]
- UNG wt Allele [NCIt concept]
- XRCC1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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