PARP1 wt Allele

Preferred Label : PARP1 wt Allele;

NCIt synonyms : Poly (ADP-Ribose) Polymerase Gene; pADPRT-1; ADPRT; ADPRT1; ADPRT 1; PARP; PARP-1; RP11-125A15.2; PPOL; Poly(ADP-Ribose) Polymerase Gene; Poly(ADP-Ribose) Polymerase 1 wt Allele; Poly (ADP-Ribose) Polymerase Family, Member 1 Gene; ADP-Ribosyltransferase (NAD ; Poly (ADP-Ribose) Polymerase) Gene; ARTD1; Poly (ADP Ribose) Polymerase 1 Gene;

NCIt definition : Human PARP1 wild-type allele is located within 1q41-q42 and is approximately 47 kb in length. This allele, which encodes poly [ADP-ribose] polymerase 1 protein, plays a critical role in DNA repair.;

NCIt note : PARP1 is localized to the nucleus and is associated with heterochromatin structures. The primary function of the gene is DNA repair.;

GenBank Accession Number : NM_001618;

Details

Origin ID

C51001;

UMLS CUI

C1709384;

Automatic exact mappings (from CISMeF team)
- ADP ribose transferases [MeSH Descriptor]
- Poly(ADP-ribose) polymerases [MeSH Descriptor]
- Poly(adp-ribose) polymerase 1 [OMIM gene]
OMIM relation
- Poly(adp-ribose) polymerase 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 1q42 [NCIt concept]
gene_is_element_in_pathway
- AIF Pathway [NCIt concept]
- Base Excision Repair Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
gene_plays_role_in_process
- Base Excision Repair [NCIt concept]
- DNA Repair [NCIt concept]
- Glycosylation [NCIt concept]
- Poly-ADP-Ribosylation [NCIt concept]
- Transcription Initiation [NCIt concept]

Keyword's position in hierarchy(ies) :

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