Poly(ADP-ribose) polymerases

Preferred Label : Poly(ADP-ribose) polymerases;

MeSH definition : Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.;

MeSH synonym : poly(adp-ribose) polymerase; poly adp ribose polymerase; poly(adp-ribose) transferase; poly(adpr) polymerase; poly adp ribose synthase; synthase, poly adp-ribose; adp-ribosyltransferase (polymerizing); polymerase, parp; parp polymerase; poly adp ribose transferase; poly adp-ribose synthase; poly(adpribose) polymerase; poly(adp-ribose) synthase;

CISMeF synonym : ADP ribosyltransferase, nuclear; ADP-Ribosyltransferase, nuclear; ADP-Ribosyltransferase, nuclear NAD ; ADPRT, nuclear; NAD ADP-Ribosyltransferase, nuclear; adenosine diphosphoribosyltransferase, nuclear; diphosphoribosyltransferase, nuclear adenosine; nuclear ADP ribosyltransferase; nuclear ADP-Ribosyltransferase; nuclear ADPRT; nuclear NAD ADP ribosyltransferase; nuclear NAD ADP-Ribosyltransferase; nuclear adenosine diphosphoribosyltransferase;

CISMeF hyponym : EC 2.4.2.-;

MeSH CAS label : NAD :poly(adenosine diphosphate D-ribose)-acceptor ADP-D-ribosyltransferase;

MeSH Related Number : nuclear ADP ribose transferases; 58319-92-9 (CAS RN);

Registry Number MeSH : EC 2.4.2.30;

Related CAS MeSH : EC 2.4.2.- (Nuclear ADP ribose transferases);

Is substance : O;

UNII : EC 2.4.2.30;

Details

Origin ID

D011065;

UMLS CUI

C0032405;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Nicotinamide adenine dinucleotide ^+^ adenosine diphosphate-ribosyltransferase (substance) [SNOMED CT concept]
- PARP1 wt Allele [NCIt concept]
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
- Poly(adp-ribose) polymerase 1 [OMIM gene]
Indexing information
- 1,5-dihydroisoquinoline [MeSH Supplementary Concept]
- 1,5-dihydroxyisoquinoline [MeSH Supplementary Concept]
- 1-(4-dimethylaminomethylphenyl)-8,9-dihydro-7H-2,7,9a-benzo(cd)azulen-6-one [MeSH Supplementary Concept]
- 10-((4-hydroxypiperidin-1-yl)methyl)chromeno(4,3,2-de)phthalazin-3(2H)-one [MeSH Supplementary Concept]
- 2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one [MeSH Supplementary Concept]
- 2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide [MeSH Supplementary Concept]
- 2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-1H-benzo(d)imidazole-4-carboxamide [MeSH Supplementary Concept]
- 2-(4-(pyridin-2-yl)phenyl)-1H-benzo(d)imidazole-4-carboxamide [MeSH Supplementary Concept]
- 2-(4-chlorophenyl)-5-quinoxalinecarboxamide [MeSH Supplementary Concept]
- 2-(4-cyclopropylmethylpiperazin-1-yl)-5H-benzo(c)(1,5)naphthyridin-6-one [MeSH Supplementary Concept]
- 2-(4-hydroxyphenyl)-1H-benzimidazole-4-carboxamide [MeSH Supplementary Concept]
- 2-(4-methylpiperazin-1-yl)-5H-benzo(c)(1,5)naphthyridin-6-one [MeSH Supplementary Concept]
- 2-(methoxycarbonyl(4-methoxyphenyl)methylsulfanyl)-1H-benzimidazole-4-carboxylic acid amide [MeSH Supplementary Concept]
- 2-methyl-4(3H)-quinazolinone [MeSH Supplementary Concept]
- 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone [MeSH Supplementary Concept]
- 3,4-dihydro-5-hydroxy-1(2H)-isoquinolinone [MeSH Supplementary Concept]
- 3,4-dihydro-5-methyl-1(2H)-isoquinolinone [MeSH Supplementary Concept]
- 3-acetamidobenzamide [MeSH Supplementary Concept]
- 3-aminobenzamide [MeSH Supplementary Concept]
- 3-methoxybenzamide [MeSH Supplementary Concept]
- 3-nitrosobenzamide [MeSH Supplementary Concept]
- 4-(3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl)-2H-phthalazin-1-one [MeSH Supplementary Concept]
- 4-amino-1,8-naphthalimide [MeSH Supplementary Concept]
- 4-carbamoylbenzenediazonium [MeSH Supplementary Concept]
- 5-aminoisoquinolinone [MeSH Supplementary Concept]
- 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido(4,3,2-de)phthalazin-3(7H)-one [MeSH Supplementary Concept]
- 5-iodo-6-amino-1,2-benzopyrone [MeSH Supplementary Concept]
- 6-amino-1,2-benzopyrone [MeSH Supplementary Concept]
- 6-nitroso-1,2-benzopyrone [MeSH Supplementary Concept]
- GPI 15427 [MeSH Supplementary Concept]
- GPI 6150 [MeSH Supplementary Concept]
- HO 3089 [MeSH Supplementary Concept]
- INO 1001 [MeSH Supplementary Concept]
- ME0328 [MeSH Supplementary Concept]
- MP 124 [MeSH Supplementary Concept]
- N-(6-oxo-5,6-dihydrobenzo(c)(1,5)naphthyridin-2-yl)-2-(4-pyrrolidin-1-ylpiperidin-1-yl)acetamide [MeSH Supplementary Concept]
- N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride [MeSH Supplementary Concept]
- benadrostin [MeSH Supplementary Concept]
- botulinum toxin type C [MeSH Supplementary Concept]
- cofpropamine [MeSH Supplementary Concept]
- epidermal cell differentiation inhibitor, staphylococcus aureus [MeSH Supplementary Concept]
- iniparib [MeSH Supplementary Concept]
- niraparib [MeSH Supplementary Concept]
- olaparib [MeSH Supplementary Concept]
- phenanthridone [MeSH Supplementary Concept]
- rucaparib [MeSH Supplementary Concept]
- talazoparib [MeSH Supplementary Concept]
- thieno(2,3-c)isoquinolin-5-one [MeSH Supplementary Concept]
Record concept(s)
- Poly(ADP-ribose) polymerases [MeSH concept]
Related MeSH Supplementary Concept(s)
- 2,3,7,8-tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase, mouse [MeSH Supplementary Concept]
- AT4G02390 protein, Arabidopsis [MeSH Supplementary Concept]
- PARP1 protein, human [MeSH Supplementary Concept]
- PARP10 protein, human [MeSH Supplementary Concept]
- PARP12 protein, mouse [MeSH Supplementary Concept]
- PARP14 protein, human [MeSH Supplementary Concept]
- PARP16 protein, Drosophila [MeSH Supplementary Concept]
- PARP16 protein, human [MeSH Supplementary Concept]
- PARP16 protein, mouse [MeSH Supplementary Concept]
- PARP2 protein, S cerevisiae [MeSH Supplementary Concept]
- PARP2 protein, human [MeSH Supplementary Concept]
- PARP3 protein, Arabidopsis [MeSH Supplementary Concept]
- PARP3 protein, human [MeSH Supplementary Concept]
- PARP3 protein, zebrafish [MeSH Supplementary Concept]
- PARP6 protein, mouse [MeSH Supplementary Concept]
- PARP9 protein, human [MeSH Supplementary Concept]
- Parp protein, Drosophila [MeSH Supplementary Concept]
- Parp1 protein, mouse [MeSH Supplementary Concept]
- Parp1 protein, rat [MeSH Supplementary Concept]
- Parp10 protein, mouse [MeSH Supplementary Concept]
- Parp14 protein, mouse [MeSH Supplementary Concept]
- Parp16 protein, rat [MeSH Supplementary Concept]
- Parp2 protein, mouse [MeSH Supplementary Concept]
- Parp2 protein, rat [MeSH Supplementary Concept]
- Parp9 protein, mouse [MeSH Supplementary Concept]
- TiPARP protein, human [MeSH Supplementary Concept]
- poly(ADP-ribose) polymerase-11, mouse [MeSH Supplementary Concept]
- poly(ADP-ribose)polymerase-2, rat [MeSH Supplementary Concept]
- vault poly(ADP-ribose) polymerase [MeSH Supplementary Concept]
Related MeSH term(s)
- Poly(ADP-ribose) Polymerase Inhibitors [MeSH Descriptor]
See also
- Poly ADP Ribosylation [MeSH Descriptor]
- poly adenosine diphosphate ribose [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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