DNA Repair Protein XRCC1

Preferred Label : DNA Repair Protein XRCC1;

NCIt synonyms : RCC; X-Ray Repair Cross-Complementing Protein 1; X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 1; XRCC1; X-Ray Repair Cross Complementing Protein 1; X-Ray Repair Cross Complementing Protein-1;

NCIt definition : DNA repair protein XRCC1 (633 aa, 69 kDa) is encoded by the human XRCC1 gene. This protein is involved in repair of both DNA strand breakage and improper sister chromatid exchange.;

NCIt note : XRCC1 is required to interact with polynucleotide kinase (PNK) and poly(ADP-ribose) polymerase, linking DNA polymerase-beta and DNA ligase III (LIG3) with single-strand break repair and short-patch base excision repair, respectively.;

Details

Origin ID

C21565;

UMLS CUI

C0250029;

Currated CISMeF NLP mapping
- X-ray repair cross complementing protein 1 [MeSH concept]
OMIM relation
- X-ray repair cross complementing 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- XRCC1 protein, human [MeSH Supplementary Concept]
- XRCC1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DNA Repair Gene [NCIt concept]
- XRCC1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- BRCT Domain [NCIt concept]
gene_product_is_element_in_pathway
- Base Excision Repair Pathway [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
- FOXM1 Transcription Factor Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Malignant Neoplasm [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair [NCIt concept]
- Single Strand Break Repair [NCIt concept]
- Sister Chromatid Exchange Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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