XRCC1 wt Allele

Preferred Label : XRCC1 wt Allele;

NCIt synonyms : X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 wt Allele; RCC; X-Ray Repair, Complementing Defective, in Chinese Hamster, 1 Gene;

NCIt definition : Human XRCC1 wild-type allele is located in the vicinity of 19q13.2 and is approximately 32 kb in length. This allele, which encodes DNA-repair protein XRCC1, is involved in the repair of single-strand DNA breaks and sister chromatid exchange. A rare microsatellite polymorphism in this allele is associated with cancer in patients of varying radiosensitivity in cancer patients.;

GenBank Accession Number : NM_006297; M36089;

Details

Origin ID

C51012;

UMLS CUI

C1705629;

OMIM relation
- X-ray repair cross complementing 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Malignant Neoplasm [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 19q13.2 [NCIt concept]
gene_is_element_in_pathway
- Base Excision Repair Pathway [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
- FOXM1 Transcription Factor Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- DNA Repair [NCIt concept]
- Single Strand Break Repair [NCIt concept]
- Sister Chromatid Exchange Process [NCIt concept]

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