DNA Topoisomerase 2-Alpha

Preferred Label : DNA Topoisomerase 2-Alpha;

NCIt synonyms : Topoisomerase, DNA, II, Alpha; Topoisomerase-II Alpha; Topoisomerase (DNA) II Alpha 170kDa; DNA Topoisomerase II, 170 kD; Topo II Alpha; Topoisomerase (DNA) II Alpha (170kD); TOP2A; DNA Topoisomerase II, Alpha Isozyme; DNA Topoisomerase II-Alpha; DNA Topoisomerase II, Alpha; Topoisomerase II Alpha; EC 5.6.2.2;

NCIt definition : DNA topoisomerase 2-alpha (1531 aa, 174 kDa) is encoded by the human TOP2A gene. This protein is involved in the modulation of DNA topology.;

NCIt note : Both DNA topoisomerase 2-alpha and -beta proteins exhibit ATP-dependent strand passage activity, but they differ in several key aspects. The beta isoform relaxes DNA in a more progressive manner than the alpha isoform and also exhibits a higher optimal KCl requirement.;

NCI Metathesaurus CUI : CL791262;

Details

Origin ID

C17801;

UMLS CUI

C4549282;

Currated CISMeF NLP mapping
- DNA topoisomerase II alpha [MeSH concept]
OMIM relation
- Topoisomerase, dna, II, alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- DNA topoisomerase II alpha [MeSH concept]
- TOP2A protein, human [MeSH Supplementary Concept]
Validated automatic mappings to NTBT
- DNA topoisomerases, type II [MeSH Descriptor]
- DNA topoisomerases, type II [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Isomerase Gene [NCIt concept]
- TOP2A Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Chloroquinoxaline Sulfonamide [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_gene_product_variant
- TOP2A NP_001058.2:p.A1515S [NCIt concept]
- TOP2A NP_001058.2:p.G1386D [NCIt concept]
- TOP2A Protein Variant [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- ATPase Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Proliferation Marker [NCIt concept]
gene_product_is_element_in_pathway
- Apoptotic DNA Fragmentation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromosome Condensation [NCIt concept]
- DNA Replication [NCIt concept]
- DNA Topology Regulation [NCIt concept]
- Transcription [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Pixantrone [NCIt concept]
- Pixantrone Dimaleate [NCIt concept]
- Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients