Chloroquinoxaline Sulfonamide

Preferred Label : Chloroquinoxaline Sulfonamide;

NCIt synonyms : chlorosulfaquinoxaline; Chlorsulfaquinoxaline; Benzenesulfonamide, 4-amino-N-(5-chloro-2-quinoxalinyl)-;

NCIt related terms : Benzenesulfonamide, 4-amino-N-[5-chloro-2-quinoxalinyl]-; CQS;

NCIt definition : A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis. This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor.;

UNII : O0408QB48D;

CAS number : 97919-22-7;

NSC code : 339004;

Codes from synonyms : CDR0000044381; NSC0339004; CDR0000045331;

Details

Origin ID

C982;

UMLS CUI

C0049111;

Currated CISMeF NLP mapping
- 5-chloroquinoxaline-2-sulfanilamide [MeSH Supplementary Concept]
- 5-chloroquinoxaline-2-sulfanilamide [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 5-chloroquinoxaline-2-sulfanilamide [MeSH concept]
- 5-chloroquinoxaline-2-sulfanilamide [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- DNA Topoisomerase 2-Alpha [NCIt concept]
- DNA Topoisomerase 2-Beta [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Double Strand Break [NCIt concept]
- DNA Repair Inhibition [NCIt concept]
- Immunosuppressive Effect [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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