DNA Topoisomerase 2-Beta

Preferred Label : DNA Topoisomerase 2-Beta;

NCIt synonyms : DNA Topoisomerase II, Beta Isozyme; Topoisomerase, DNA, II, Beta; Topoisomerase (DNA) II Beta 180kDa; TOP2B; DNA Topoisomerase II, 180 kD; Topoisomerase (DNA) II Beta (180kD); Topo II Beta; Topoisomerase II Beta; EC 5.6.2.2; Topoisomerase-II Beta;

NCIt definition : DNA topoisomerase 2-beta (1626 aa, 183 kDa) is encoded by the human TOP2B gene. This protein plays a role in DNA relaxation.;

NCIt note : Both DNA topoisomerase 2-alpha and -beta proteins exhibit ATP-dependent strand passage activity, but they differ in several key aspects. The beta isoform relaxes DNA in a more progressive manner than the alpha isoform and also exhibits a higher optimal KCl requirement.;

Details

Origin ID

C17802;

UMLS CUI

C1504636;

Currated CISMeF NLP mapping
- DNA topoisomerase II beta [MeSH concept]
OMIM relation
- Topoisomerase, dna, II, beta [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- TOP2B protein, human [MeSH Supplementary Concept]
- TOP2B protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Isomerase Gene [NCIt concept]
- TOP2B Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Chloroquinoxaline Sulfonamide [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- ATPase Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Proliferation Marker [NCIt concept]
gene_product_is_element_in_pathway
- Gene Expression Regulation by Vitamin D Receptor Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromosome Condensation [NCIt concept]
- DNA Replication [NCIt concept]
- DNA Topology Regulation [NCIt concept]
- Transcription [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Topoisomerase-II-beta Inhibitor Racemic XK469 [NCIt concept]

Keyword's position in hierarchy(ies) :

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