Topoisomerase-II-beta Inhibitor Racemic XK469

Preferred Label : Topoisomerase-II-beta Inhibitor Racemic XK469;

NCIt synonyms : 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid; Propanoic acid, 2-[4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy]-, ( )-(R)-;

NCIt related terms : R( )XK469; XK469;

NCIt definition : The R-isomer of a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R( )XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R( ) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. (NCI05);

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called topoisomerase inhibitors.;

NSC code : 698215;

Codes from synonyms : CDR0000045067;

Details

Origin ID

C2662;

UMLS CUI

C0765292;

Automatic exact mappings (from CISMeF team)
- 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionic acid [MeSH concept]
- 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionic acid [MeSH Supplementary Concept]
- XK 469 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- XK 469 [MeSH concept]
- XK 469 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA Topoisomerase 2-Beta [NCIt concept]

Keyword's position in hierarchy(ies) :

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